Arizona Cardinals wide receiver Marvin Harrison Jr. left Sunday's game against the Colts in the second quarter due to a concussion after hitting his head on the turf following a 21-yard catch.

Harrison, who recorded two catches for 32 yards before leaving, will not return to the game, marking his second concussion in the NFL.

He was evaluated for a concussion at the sideline injury tent, walked to the locker room, and was ruled out at the start of the second half.

Harrison's absence in the second half impacted the Cardinals' offensive performance, which scored two touchdowns but ultimately lost 31-27 to the Colts.

He finished his rookie season with 62 catches, 885 yards, and eight touchdowns.

Harrison has been Arizona's top pass-catcher this season with 20 receptions for 306 yards, showing improvement despite some criticism about target numbers.

Jonathan Taylor's late 1-yard touchdown run sealed the victory for the Colts, overcoming the Cardinals' efforts.

This game was Harrison's first in Indianapolis, where his Hall of Fame father played for the Colts, making the matchup personally significant for him.

Arizona's quarterback Kyler Murray explained that Harrison's lower target count was due to game plan strategies, not a lack of effort or talent.

This is Harrison's second concussion in the NFL; he previously suffered one in Week 6 of the previous season but returned the following week.

He will need to clear the league's concussion protocol before returning to play.