The findings have been published in prestigious journals such as Advanced Materials and Nature Communications, highlighting the technology's potential in both diagnosis and therapy.

In addition to their work on cancer detection, the team is also developing an inhalable lung cancer treatment in partnership with Dr. Chien-Chung Lin from NCKU Hospital.

Plans are also in place to develop a therapeutic application for lung cancer in collaboration with medical professionals at NCKU Hospital.

A research team led by Chair Professor Chen-Sheng Yeh at National Cheng Kung University has developed a revolutionary cancer detection method that utilizes gold nanoparticles and electroactive liposomes, eliminating the need for fluorescent dyes.

This innovative approach relies on laser light and surface-enhanced Raman scattering (SERS) to achieve ultra-sensitive detection of cancer cells, capable of identifying as few as five cells due to the stronger Raman signal produced by cancer cells compared to normal ones.

Large-animal trials on dogs have demonstrated significant tumor cell apoptosis with minimal side effects, contrasting sharply with traditional chemotherapy treatments.

Currently, collaboration is underway with Leadgene Biotech to develop diagnostic products, focusing on the commercialization of detection tools before moving to therapeutic applications.

Initial efforts are concentrating on diagnostic tools, as they are generally easier to bring to market compared to cancer treatments that require extensive clinical trials.

The electroactive liposomal membranes, derived from Shewanella oneidensis, facilitate electron transfer from cancer cell mitochondria to gold nanoparticles, enabling both the detection and destruction of cancer cells.

The technology is being commercialized through partnerships with local biotech firms, and patent filings are underway in the U.S. and Taiwan.

In laboratory tests, this method has successfully eradicated over 90% of liver cancer cells and eliminated more than 80% of breast cancer cells, showcasing its broad therapeutic potential without the harsh side effects associated with conventional chemotherapy.

The team's work reflects a collaborative effort among experts in various fields, aiming to advance personalized medicine and improve cancer treatment outcomes.