Authorities have advised motorists to avoid the area and stay updated through NCDOT traffic alerts.

Firefighters worked tirelessly to contain the fire, which was fueled by the truck's contents, and prevent it from spreading to nearby areas.

The North Carolina Regional Hazmat Team and Eastern Environmental Services are overseeing the cleanup and removal of the damaged vehicles.

A tractor-trailer carrying fuel exploded on Interstate 40 in Sampson County, North Carolina, following a multi-vehicle crash on April 29, 2025.

However, the driver of another vehicle involved sustained serious injuries and was also transported to a hospital.

Cleanup efforts are expected to last several hours, with some lanes reopening as the situation stabilizes.

The driver of the tanker truck was airlifted to WakeMed Hospital for treatment, while no fatalities have been reported.

To combat the intense flames, crews transported water using trucks and established a drop tank for firefighting efforts.

The incident caused significant traffic disruptions, with both eastbound and westbound lanes of I-40 closed, leading to backups stretching for miles.

The cause of the crash is under investigation, with initial reports suggesting that alcohol may have played a role.

Emergency services responded promptly, battling the blaze and managing the chaotic scene.

Video footage captured the dramatic scene, showcasing flames and thick smoke visible from miles away.