Sound Waves Influence Gene Expression: New Study Reveals Potential for Non-Invasive Treatments
April 27, 2025
Moreover, the study found that cells physically expanded and altered their focal adhesions, behaving as if they were in a stiffer environment due to sound exposure.
A recent study from Kyoto University has revealed that sound waves can significantly influence cellular behavior and gene expression, suggesting that cells may respond to sound vibrations.
The research demonstrated that cells could 'remember' previous sound exposure, exhibiting a diminished response when re-exposed to sound after a 24-hour pause.
Specifically, continuous exposure to 440 Hz tones led to a significant reduction of over 70% in the expression of fat-related genes in pre-fat cells, hinting at potential applications in fat prevention.
This discovery suggests promising applications in non-invasive medical treatments, where sound could be used to influence gene activity related to inflammation and fat production.
In the study, 42 genes showed changes in expression after two hours of sound exposure, which increased to 145 genes after 24 hours, many of which are associated with mechanical sensing, inflammation, and tissue remodeling.
Different sound frequencies, including low-frequency (440 Hz) and high-frequency (14 kHz) tones, elicited varied responses from the cells, indicating that frequency plays a crucial role in cellular reaction.
Researchers utilized a vibration transducer to emit acoustic waves into cell cultures, testing various frequencies at an intensity of 100 pascals.
These findings challenge traditional views of sound as merely an auditory experience, proposing that it may serve as a significant biological signal for cellular functions.
Overall, these findings open new avenues for understanding the connection between sound and biology, with implications for cell therapy, bioengineering, and developmental biology.
However, while the effects observed in the study are promising, it remains uncertain whether similar results would occur in humans, necessitating further research.
Summary based on 2 sources
Get a daily email with more Science stories
Sources

ZME Science • Apr 24, 2025
Your Cells Can Hear You — And It Could Be Important for Fat Cells
El Adelantado News • Apr 27, 2025
Scientists in shock - they discover that your cells can "hear" sounds and change their genetic