Breakthrough Chimeras Target Folate Receptors to Degrade Cancer Proteins
June 13, 2025
Among the significant papers cited are those focusing on lysosome-targeting chimeras and their applications in cancer, along with the effectiveness of bispecific aptamer chimeras for protein degradation.
The study references various important works that explore targeted protein degradation mechanisms, advancements in cancer treatment, and the crucial role of folate receptors in cancer biology.
Recent research has unveiled the development of polyvalent folate receptor-targeting chimeras designed to effectively degrade membrane proteins.
This innovative approach highlights the significant potential of chimeras in the realm of targeted protein degradation, particularly within cancer therapy.
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Nature • Jun 13, 2025
Polyvalent folate receptor-targeting chimeras for degradation of membrane proteins