Led by Dr. Akihito Ishigami from the Tokyo Metropolitan Institute for Geriatrics and Gerontology, the research reveals that vitamin C facilitates the removal of methyl groups from DNA, which silences certain genes and activates them to enhance skin cell growth and repair.

The study identified over 10,138 regions of hypomethylation in skin models, leading to a notable increase in the expression of genes related to skin proliferation, underscoring vitamin C's role in promoting DNA demethylation.

Vitamin C's action is linked to TET enzymes, which require iron in its Fe2+ form to function, and the vitamin helps maintain this process by converting Fe3+ back into Fe2+.

A recent study published in the Journal of Investigative Dermatology highlights the significant anti-aging effects of vitamin C on skin at both the cellular and genetic levels, promoting skin thickness and cell regeneration.

After 14 days of treatment, the models showed increased thickness in the inner layer of skin and a reduction in the outer layer, confirming vitamin C's positive effect on skin cell division.

In lab experiments using human epidermal equivalents, vitamin C was applied in two concentrations, resulting in increased thickness of the living skin layer over a 14-day period, indicating enhanced keratinocyte production.

The application of vitamin C in concentrations of 1.0 and 0.1 led to thicker epidermal layers while not significantly affecting the outer layer of dead cells, highlighting its role in promoting keratinocyte proliferation.

Vitamin C, also known as ascorbic acid, is a vital antioxidant that not only supports skin health by synthesizing collagen but also enhances immune function by boosting white blood cell activity.

The article emphasizes the importance of obtaining vitamin C from dietary sources, such as fruits and vegetables, rather than relying solely on supplements for optimal health.