The Fight Aging! Newsletter, published on April 14, 2025, is dedicated to advancing the understanding and treatment of age-related diseases through innovations in medicine and biotechnology.

Reaching thousands of subscribers weekly, the newsletter features key articles that explore topics such as neurogenesis, cellular senescence, exercise benefits, and novel therapeutics for aging.

In its upcoming issue, the newsletter will delve into various subjects, including the impact of cellular senescence on ovarian aging and the development of fluid biomarker assays for diagnosing neurodegenerative diseases.

OneSkin's recent study on the topical senotherapeutic OS-01 suggests it may enhance skin function and reduce systemic inflammation by targeting senescent cells.

Physical activity is shown to significantly influence skeletal muscle health and metabolism, potentially reducing cellular senescence and improving overall health in aging populations.

Research indicates that the burden of senescent cells in obese individuals can vary and may respond positively to exercise, although the effects are less pronounced compared to senolytic therapies.

Studies on neurogenesis reveal its decline with age, which has significant implications for cognitive function, particularly in Alzheimer's disease, underscoring the need for effective strategies to enhance neurogenesis.

Ongoing research has identified distinct inflammatory gut microbiomes in Alzheimer's patients, suggesting a potential link between gut health and neurodegenerative diseases.

The development of fluid biomarkers from blood, saliva, and urine is underway as a non-invasive method for diagnosing conditions like Alzheimer's and Parkinson's.

A recent study emphasizes that it's never too late to begin exercising, even for those with hypertension, as physical activity is associated with lower mortality rates and improved health outcomes.

Innovative SIRT6 gene therapy is currently being tested in dogs, with hopes that it may extend healthspan and provide insights for future human treatments.

Research into the differences in DNA structure between short-lived and long-lived species may offer valuable insights into the mechanisms of longevity and aging.