Despite increases in life expectancy, the health span has not seen similar improvements, underscoring the urgent need for strategies to combat aging and promote healthy aging.

Metabolic syndrome (MetS) encompasses a range of metabolic dysfunctions that can lead to serious health issues, including type 2 diabetes and cardiovascular diseases.

Aging is a multifaceted process influenced by genetic, environmental, and stochastic factors, leading to various age-related diseases and increased mortality.

H2 has shown biological effects that target aging processes and help manage metabolic disorders through its antioxidative and anti-inflammatory mechanisms.

Genomic instability, marked by accumulating DNA damage, plays a significant role in the aging process and the development of age-related diseases.

As the global population ages, the prevalence of age-related diseases is expected to rise, emphasizing the importance of developing effective strategies for healthy aging.

Molecular hydrogen (H2) has emerged as a promising therapeutic gas, recognized for its high bioavailability in tissues and antioxidative properties.

Research indicates that H2 treatment can enhance insulin sensitivity and improve lipid profiles in rodent models, suggesting its potential in managing metabolic syndrome.

The effectiveness of H2 treatment is influenced by factors such as dosage, duration, and administration route, which affect its pharmacokinetics and tissue distribution.

While studies indicate that H2 treatment has few mild adverse effects, further research is necessary to fully understand its safety in both pathological and physiological contexts.