The XPRIZE Healthspan initiative has launched the Ovarian Health XPRIZE to advance measurement and solutions for ovarian aging, emphasizing its systemic role beyond fertility and its impact on women's overall health and aging.

This initiative aims to establish ovarian function as a measurable health category, creating new standards, data ecosystems, and regulatory dialogue, shifting perceptions of women's health to include life-course ovarian health rather than focusing solely on reproductive aspects.

Ovarian function significantly influences cardiovascular, neurological, immune, and metabolic health, yet current tools and understanding are inadequate for comprehensive assessment across a woman’s lifespan.

Research indicates that ovarian decline accelerates health deterioration during reproductive and post-menopausal years, but the lack of validated biomarkers and measurement frameworks hampers progress, partly due to limited animal models and historical neglect of female-specific biology in longevity studies.

Barriers such as scientific challenges, regulatory biases against female-focused research, and underfunding of women’s health are being addressed through prizes designed to attract diverse innovators and overcome these obstacles.

The prize design begins in 2025 with workshops, partial funding, and a target launch in early 2026, with a competition lasting three to five years focused on health systems, direct-to-consumer tools, and frontier technologies to make ovarian health measurable and impactful.

Global inclusivity and scalability are prioritized, with considerations for affordability and access in low- and middle-income countries, aiming to reach the 1.9 billion women worldwide affected by ovarian health issues.

The initiative seeks to stimulate the development of biomonitoring tools, biomarkers, and applications to interpret ovarian signals, facilitating early detection and system-wide health interventions beyond therapeutics.