Recent advances in aging research include measuring cellular senescence through gene expression scores from blood samples, which correlate with health outcomes like multimorbidity, cognitive decline, and mortality.

Studies indicate that alternative splicing regulation varies across species and influences maximum lifespan, with conserved splicing events in the brain linked to longevity.

Research on sex differences in aging shows women, despite living longer, tend to experience higher frailty and disease burden in later life, partly due to differences in immune system aging and inflammatory biomarkers such as IL-6, IL-10, and TNF-α.

Maintaining physical fitness is strongly associated with delaying the onset of chronic age-related diseases, underscoring the importance of staying active for longevity.

The Fight Aging! newsletter from October 27th, 2025, highlights recent developments in aging and longevity research, focusing on biological mechanisms and potential interventions.

Research shows that the diabetes drug canagliflozin improves brain aging markers and reduces Alzheimer's pathology in male mice, but not in females, indicating sex-specific effects in neuroprotection.

Aging visceral fat promotes inflammation by increasing FMO3 expression in adipocytes, which converts microbiome-derived trimethylamine into TMAO, further aggravating systemic inflammation and metabolic issues.

Exercise can partially reverse age-related loss of muscle tissue capillary density, with benefits depending on the type of activity and baseline vascular health, supporting lifestyle interventions for healthy aging.