The European AIDS Clinical Society (EACS) guidelines highlight the importance of managing comorbidities in an aging HIV population, with only minor changes to first-line ART regimens.

Prevention strategies now include long-acting injectable PrEP, with testing recommendations before initiation and guidance for postexposure prophylaxis in PrEP users.

Vaccination updates include new recommendations for RSV vaccines for those aged 75 and older, along with revised hepatitis B vaccination protocols that feature new vaccines to improve responses in people with HIV.

First-line antiretroviral therapy (ART) remains largely unchanged, focusing on second-generation integrase inhibitors, with doravirine still an option, and specific guidance for diagnosing and treating HIV-2 due to rising cases in Europe.

Cancer screening protocols have been updated for several cancers, including hepatocellular carcinoma, with efforts to enhance access and screening rates.

Guidelines now feature revised terminology and dosing guidelines for tuberculosis and other opportunistic infections, along with updated antiviral guidance for mpox, emphasizing immune support over antivirals in many cases.

The updated HIV guidelines now emphasize a holistic approach to care, including expanded recommendations on vaccination, cardiovascular risk management, cancer screening, mental health, and prevention strategies.

Cardiovascular health is a major focus, recommending earlier initiation of statins, lowering hypertension thresholds, and addressing obesity through lifestyle changes, medications, and bariatric procedures.

HIV management in pregnancy has been refined with new details on viral load monitoring, cesarean timing, and ART initiation during labor, alongside updates on pediatric care and adolescent transition.

The guidelines introduce new mental health screening tools, substance use assessments, and interventions targeting issues like chemsex and sleep health, supporting comprehensive patient care.