Vargas was injured while attempting to stretch for a wide throw from Curtis Mead during a play involving Aaron Judge, with Judge's leg striking Vargas's hand.

Vargas expressed hope that his wrist would improve after further testing, which was scheduled for the following day, and reflected on the play that led to his injury, noting he was focused on making the out and did not expect contact.

Prior to the injury, Vargas hit his first career grand slam in the second inning, tying the game at 4 and highlighting his recent importance to the team.

The game was notable for Vargas's early offensive contribution, which tied the game at 4, but the White Sox ultimately lost due to defensive errors and the Yankees' offensive performance.

The White Sox committed three errors and allowed three home runs in the game, which contributed to their poor performance.

During the play, Judge was awarded a single, advanced to second on the throw, and Ben Rice scored from first, giving the Yankees a 6-4 lead in that inning.

Vargas's injury was compounded by the White Sox already missing key players Luis Robert Jr. and Colson Montgomery, and manager Will Venable described Vargas as a vital player who sets the tone for the team.

Vargas expressed fear and discomfort about his injury postgame, hoping for recovery soon, while his injury adds to the White Sox's recent struggles with multiple key players on the injured list.

The White Sox are considering moving Vargas to the injured list and promoting first baseman Tim Elkow from Charlotte to fill the roster gap as they prepare for their next game against the Yankees' Carlos Ródon.

The game highlighted defensive struggles on both sides, impacting the outcome and emphasizing the need for improved team defense.

Starting pitcher Davis Martin acknowledged issues with walks and long counts but saw positives in his performance despite the team's 48-86 record, matching their season's low point.

General manager Chris Getz praised Vargas's confidence and aggressive play, noting his positive impact and recent development.

Chicago White Sox first baseman Miguel Vargas left Thursday's game against the Yankees in the fifth inning due to a left wrist contusion, after hitting his first career grand slam earlier in the game.