Three of the seven games carry spreads of one possession or fewer, including the headliner No. 6 Louisville at No. 25 Arkansas, underscoring potential for more upsets.

The piece includes links to related coverage, team pages, and CBS Sports analyst excerpts, with SportsLine offered for model-based picks.

Over half of the seven Wednesday games feature SEC teams as the betting favorites, signaling a possible SEC resurgence after last year’s strong showing.

The preview follows a chaotic Tuesday with multiple upsets and a Duke win over Florida, setting the stage for Day 2 of the 2025 ACC/SEC Challenge.

We preview Wednesday’s ACC/SEC Challenge with several marquee picks, including Louisville favored by 3.5 at Arkansas, Clemson at Alabama with Alabama favored by 10.5, LSU minus 7.5 at Boston College, Auburn minus 8.5 at NC State, Texas favored by 2.5 at Virginia, Vanderbilt minus 10.5 at SMU, and Mississippi State minus 3.5 at Georgia Tech.

Each game comes with a brief rationale covering form, home/away factors, and key matchups, forming a concise wagering preview.