Indiana rolls with depth, featuring five players in double figures led by Tucker DeVries at 16.8 PPG, while Louisville counters with four double-figure scorers led by Ryan Conwell at 19.5 PPG.

The game is part of CBS’s Saturday slate of top-ranked matchups, highlighting Indiana vs. Louisville alongside other premier nonconference games.

Indiana, ranked No. 22, seeks redemption after a 73-64 loss at Minnesota and aims to prove it belongs among the sport’s elite by knocking off a top-ranked Louisville club.

Louisville arrives off its first defeat of the season, an 89-80 loss at Arkansas, after opening 7-0 with high-profile wins over Kentucky and Cincinnati, and will look to rebound on the neutral court.

The betting outlook centers on Louisville’s potent offense versus Indiana’s stingy defense, with the spread initially favoring Louisville by 5.5 points but considered excessive given Indiana’s strong start.

In a marquee Saturday showdown at Gainbridge Fieldhouse, Louisville and Indiana collide on a neutral floor that feels like a de facto home game for Indiana, with the main event set for 2:15 p.m. ET on CBS.

CBS writers offer prediction commentary favoring a closer game, leaning toward a Louisville win but pointing to Indiana +5.5 as the smarter spread bet for the matchup.

The key on-court matchup pits Louisville’s high-scoring offense, heavy on three-pointers, against Indiana’s solid defense, which ranks highly in two-point percentage allowed and overall effective field goal percentage defense.