The Buffalo Bills are aiming to secure their first Super Bowl title in 2025 after a series of strong performances over the past five years.

Having retained most of their roster from the previous season, which included a trip to the AFC Championship Game, the Bills are poised for another competitive year.

In the 2024 season, the team finished with a 13-4 record, won the AFC East, and reached the AFC Championship Game, tying their franchise record for most wins in a season.

As of June 2025, sportsbooks list the Bills as having the shortest odds among Super Bowl contenders, reflecting their strong potential for success this season.

Reasons to bet on the Bills include their impressive scoring record and a favorable schedule, which positions them well for a strong season.

Sportsbooks are offering various odds for Bills-related bets, including win totals and playoff chances, with a total win line set around 11.5 to 12.5 games.

Significant offseason changes include the addition of Joey Bosa to replace Von Miller at edge rusher and the drafting of Maxwell Hairston to strengthen the cornerback position.

However, concerns remain regarding a potential drop in defensive performance and turnover regression, which could impact their success this season.

Quarterback Josh Allen, who won the MVP award in 2024, remains a key player for the team, despite experiencing a dip in passing yards and touchdowns compared to previous seasons.

Key betting recommendations suggest wagering on the Bills to secure the AFC No. 1 seed while betting against Allen's passing totals due to the lack of new offensive weapons.

Historically, the Bills have the highest number of wins (61) over a five-season span without reaching a Super Bowl and were the only team since 1960 to finish a season with a negative turnover margin.