Before joining the Rams, Humphries finished the 2024 season with the Kansas City Chiefs, where he made his debut in Week 14 against the Los Angeles Chargers.

However, his time with the Chiefs was marred by a hamstring injury that forced him to leave the game early against the Chargers, and he did not return to the starting lineup until Week 18.

During the playoffs, Humphries was not selected for the starting position, with guard Joe Thuney taking over at left tackle for the Chiefs.

Prior to his stint with the Chiefs, Humphries suffered a torn ACL late in the 2023 season while playing for the Arizona Cardinals.

At 31 years old, Humphries has had a notable career, playing eight seasons with the Cardinals after being drafted in the first round in 2015.

Throughout his career, he has participated in 100 NFL games and earned a Pro Bowl selection in 2021, showcasing his skills as a top offensive lineman.

With the addition of Humphries, the Rams' offensive line, already bolstered by veteran right tackle Rob Havenstein, gains valuable depth as they aim to maximize their championship window with quarterback Matthew Stafford.

On June 12, 2025, the Los Angeles Rams announced the signing of offensive tackle D.J. Humphries, a former Pro Bowler.

This signing marks a significant shift in the NFC West, especially after the San Francisco 49ers were unable to finalize a contract with Humphries earlier in the offseason.

Humphries had initially agreed to a deal with the 49ers in April 2025 but ultimately did not sign, prompting the team to explore other options.