The Denver Broncos are set to open the 2025 NFL season at home against the Tennessee Titans, featuring rookie quarterback Cam Ward in what will be the first rookie QB matchup for the Broncos since 1970.

The Titans' offensive coordinator highlighted the importance of Ward's footwork to maintain accuracy against Denver's aggressive secondary, which is expected to be even more assertive this season.

This game marks the first time since 2023 that the Broncos face a rookie quarterback, continuing a positive trend with a 15-10 record against rookie starters since 2000, including notable performances like Patrick Mahomes' first start.

Ward's debut will be tested by Denver's formidable pass rush, which finished last season as the league's third-best in scoring defense and sacks, making his footwork and accuracy crucial against their assertive secondary.

The Broncos' defense, which has been reinforced with new players like linebacker Dre Greenlaw and safety Talanoa Hufanga, aims to continue its strong performance from last season.

Denver's defense, led by star corner Pat Surtain II, is expected to be aggressive and is bolstered by a strong pass rush including Nik Bonitto, Jonathon Cooper, and Zach Allen, aiming to challenge Ward's limited preseason experience.

Coach Sean Payton emphasizes starting fast this season to avoid slow starts that have hampered previous campaigns, with an eye on improving playoff positioning.