The Indianapolis Colts are facing a series of unexpected injuries during pregame warmups before their Week 6 game against the Arizona Cardinals, which has impacted their roster significantly.

Notably, the team lost cornerback Charvarius Ward and former quarterback Anthony Richardson during these warmups, adding to their challenges.

Charvarius Ward, the team's top cornerback, suffered a concussion after colliding with a teammate who ran onto the field at high speed, and was not wearing helmet or pads at the time, ruling him out for the game.

Ward, 29, has been a key player this season, signing a three-year, $60 million deal, and is ranked as the third-highest graded cornerback by Pro Football Focus, contributing significantly to the Colts' defensive success.

His injury worsens a critical shortage at the cornerback position, already strained by other injuries and retirements, with players like Kenny Moore and Justin Walley also unavailable.

Meanwhile, quarterback Anthony Richardson sustained an eye injury while stretching with a resistance band during warmups, which led to him being listed as the backup and not participating in the game.

Richardson's injury adds to the team's quarterback challenges, as Riley Leonard was elevated to backup quarterback in his absence.

These injuries are particularly surprising given the Colts' impressive 4-1 record this season, and they now face the difficult task of managing these setbacks.

Overall, the Colts' secondary and quarterback depth are under significant strain, threatening to impact their season despite their unexpected success.