A collaborative study by Caltech and Japanese researchers uncovers new insights into the limb regeneration abilities of mutant newts.

The newts can regrow perfectly formed limbs after removal of deformed appendages, suggesting distinct processes for limb generation and regeneration.

Research identifies the molecule fibroblast growth factor 10 (FGF10) as crucial for limb development, but less so for regeneration, hinting at a different growth factor's role.

FGF8, influenced by nerve-derived factors, is hypothesized to be more significant in the regeneration process, particularly for nerve cell development in re-grown limbs.

The study emphasizes the importance of nerves in regeneration and suggests the potential for future research on bio-inspired regenerative medicine for humans.

Findings are published in the journal Proceedings of the National Academy of Sciences, indicating peer-reviewed validation of the research.