Neurodegenerative diseases, which are chronic conditions affecting neuron functionality, are becoming increasingly prevalent due to aging populations.

These disorders, including Alzheimer's disease and frontotemporal dementia, share similar mechanisms and therapeutic challenges.

Tauopathies, characterized by the accumulation of tau protein, disrupt axonal transport and contribute to neurodegeneration.

Understanding the pathomechanisms linking metabolic diseases to tauopathies is crucial for early diagnosis and treatment.

Observations indicate a coexistence of metabolic disorders and tauopathic syndromes, suggesting that managing these conditions could influence the progression of neurodegenerative diseases.

Diet and environmental factors significantly impact gut microbiome composition, which can be altered in neurodegenerative disorders.

Recent research underscores the connections between diet, gut microbiota, and human health, particularly in relation to neurodegenerative conditions.

The interaction between gut microbiota and bioactive polysaccharides (BPs) has significant implications for health, especially in cardiometabolic diseases.

Short-chain fatty acids (SCFAs), produced by certain gut bacteria, are essential for immune function and gut health.

Novel Foods, defined as foods not consumed by humans in the EU before 1997, are gaining attention for their potential effects on the microbiome.

Further research, including cohort studies, is needed to explore the link between metabolic diseases and tauopathies, potentially leading to new treatment options.

The need for larger studies to identify specific microorganisms related to neurodegenerative disorders is emphasized, as microbial diversity may play a role in disease pathology.