Study Links PCOS and Endometriosis to Increased Cardiovascular Risk in Women
March 5, 2025
Specifically, the study highlighted that women with these conditions have a 41% higher risk of ischemic heart disease and a 33% increased risk of cerebrovascular disease.
A recent study published in the journal Heart has revealed a significant link between common gynecological issues, such as polycystic ovary syndrome (PCOS) and endometriosis, and an increased risk of cardiovascular disease.
Analyzing data from over 3.2 million women across 28 studies, the research found that women with these gynecological disorders face a 28% greater risk of composite cardiovascular disease.
Additionally, women experience about 55,000 more strokes each year than men, making stroke the third leading cause of death for women.
Interestingly, the study noted that the increased cardiovascular risk associated with these gynecological conditions may manifest relatively early in life, underscoring the need for early intervention and monitoring.
The researchers also acknowledged limitations in their study, noting that many of the reviewed studies had a high risk of bias and did not comprehensively cover all aspects of cardiovascular disease, indicating a need for more high-quality research.
Cardiovascular disease remains the leading cause of death among women in the US, accounting for nearly 500,000 deaths annually, surpassing deaths from all cancers combined.
The hormonal imbalances in PCOS and the abnormal tissue growth in endometriosis are believed to contribute to the heightened cardiovascular and cerebrovascular risks observed in affected women.
Mathew Leonardi, one of the study's authors, stressed the importance of understanding the long-term health implications of these gynecological conditions on women's cardiovascular health and overall quality of life.
PCOS, which affects approximately 5 to 6 million women in the US, is characterized by hormonal imbalances impacting the ovaries, while endometriosis affects over 6.5 million women, causing pelvic pain and fertility issues.
The study also pointed out that over 10 million women in the US suffer from heavy menstrual bleeding, which can lead to anemia, and that menstrual irregularities affect 14% to 25% of women of childbearing age.
This research emphasizes the critical need for healthcare providers to recognize and address the cardiovascular risks associated with gynecological disorders to improve women's health outcomes.
Summary based on 2 sources
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Sources

New York Post • Mar 4, 2025
These 4 reproductive issues have just been linked to heart disease — one affects 25% of women
Medical Daily • Mar 5, 2025
Can Gynecological Issues Raise Risk Of Heart Diseases? Here're Two Conditions That Pose Greatest Danger