A recent study has found that adults with ADHD show brain changes similar to those seen in early-stage dementia, including elevated iron levels and increased neurofilament light chain (NfL) in the blood.

Led by Professor Paul G. Unschuld, the research underscores the need for understanding the mechanisms that contribute to the heightened dementia risk in individuals with ADHD.

The findings highlight the critical importance of early diagnosis and management of ADHD, which could enhance quality of life and potentially reduce long-term cognitive health risks.

ADHD affects approximately 3.5% of adults, characterized by attention difficulties, impulsivity, and hyperactivity, often continuing into adulthood and impacting daily functioning.

Globally, around 55 million people are affected by age-related dementias, with Alzheimer's disease representing 60-70% of these cases, according to 2023 WHO statistics.

Each year, nearly 10 million new cases of dementia are diagnosed worldwide, primarily due to Alzheimer's disease, which remains a significant public health concern.

This important research was funded by a SPARK grant from the Swiss National Science Foundation, awarded to Professor Unschuld.