Shilatifard's research primarily focuses on childhood leukemia, exploring the mechanisms of transcription elongation and chromosomal translocations, which have led to new cancer treatment approaches currently in clinical trials.

Ali Shilatifard, a distinguished alumnus of Kennesaw State University, has made history by being elected to the National Academy of Sciences, becoming the first graduate from KSU to achieve this prestigious honor.

In 2025, he was one of 120 American inductees and 30 international honorees recognized for his significant contributions to scientific research.

Additionally, in 2023, he was elected to the American Academy of Arts and Sciences, further highlighting his esteemed career in science.

The National Academy of Sciences, founded in 1863, now comprises 2,662 active members and 556 international members, and it provides scientific advice to the U.S. government.

He leads the Cancer Epigenetics and Nuclear Dynamics Program at Northwestern University's Robert H. Lurie Comprehensive Cancer Center, furthering his impactful work in cancer research.

Currently, he holds the position of Robert Francis Furchgott Professor and chair of biochemistry and molecular genetics at Northwestern University's Feinberg School of Medicine.

Overcoming homelessness in his earlier years, Shilatifard earned a doctorate from the University of Georgia and Oklahoma in 1994, showcasing his resilience and determination.

His pioneering work has led to the development of new therapeutic approaches for cancer treatment, with several drugs based on his findings currently undergoing clinical trials.

Shilatifard has also held significant editorial roles, including serving as a senior editor for the journal Science and founding editor for Science Advances.

He graduated from KSU in 1989 with a Bachelor of Science in Organic Chemistry, crediting the university for opening doors in his academic and professional journey.

In 2023, he returned to KSU to deliver a lecture on epigenetics and was honored with the Distinguished Alumni Award from the College of Science and Mathematics.