MammaPrint Revolutionizes Breast Cancer Treatment: Many Women Avoid Chemotherapy with Genetic Testing
May 25, 2025
Genomic testing has significantly transformed the experience of women facing breast cancer, particularly in how personalized treatment plans are developed.
A groundbreaking genetic test known as MammaPrint allows many women with early-stage breast cancer to avoid chemotherapy, which has been a standard part of treatment.
Recent findings indicate that nearly half of women with early-stage breast cancer have a low genetic risk of recurrence, with 20% of those previously deemed 'high-risk' now reclassified as 'low risk'.
Dr. Laura Esserman, a prominent breast cancer specialist, highlights the critical role of understanding cancer genetics in creating tailored treatment plans.
This genomic testing analyzes the genetic makeup of cancer cells to evaluate tumor aggression and the potential benefits of chemotherapy.
The MammaPrint test assesses the activity of 70 genes to determine the likelihood of cancer recurrence, with a recent study involving 6,700 women confirming its reliability.
By leveraging the genetic profiles of tumors, healthcare providers can make more informed treatment decisions, ultimately enhancing patient outcomes and quality of life.
For women identified as low risk by the MammaPrint test, hormone therapy options such as tamoxifen or anastrozole are available, which are less debilitating than chemotherapy, despite still having side effects.
This woman's experience exemplifies a broader shift in cancer treatment from a one-size-fits-all approach to a more personalized medicine model.
The findings from the MammaPrint study represent a hopeful advancement toward personalized cancer care, steering away from conventional treatment methods.
Her journey serves as a hopeful testament to the advancements in science and technology within healthcare, emphasizing that knowledge is power in the fight against cancer.
This advancement marks a significant shift from traditional treatment decisions based solely on tumor size and hormone receptor status to a more individualized approach based on genetic risk scores.
Summary based on 2 sources
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Sources

Economic Times • May 25, 2025
Breakthrough Cancer test allows more Breast Cancer patients to skip Chemotherapy
GreaterGood • May 20, 2025
How Genomic Testing Transformed One Woman's Breast Cancer Journey