A study on inflammatory cGAS-STING signaling is also presented, revealing its influence on photoaging of the skin and linking chronic inflammation and cellular senescence to skin aging.

Among the featured articles is a review of mitochondrial dysfunction in aging, emphasizing the critical role of mitochondria in cellular processes and their decline in aged tissues.

Additionally, the newsletter discusses S-sulfhydration as an anti-inflammatory mechanism, illustrating its significance in modulating mitochondrial function and reducing oxidative stress during aging.

In an exciting development, ALDH1A2 overexpression in mice has been shown to enable ear tissue regeneration, offering insights into regenerative capacity and potential therapeutic applications for humans.

Lastly, researchers introduce a novel drug named SANA, derived from salicylate, which promotes thermogenesis and weight loss without relying on uncoupling protein 1, indicating promising applications in obesity treatment.

The latest edition of the Fight Aging! Newsletter, dated July 7th, 2025, highlights recent advancements in understanding and combating age-related diseases through modern medicine.

The newsletter further explores the relationship between insulin resistance and Alzheimer's disease, trends in cardiovascular mortality, and the beneficial effects of long-term physical activity on cognitive decline.

In another significant finding, researchers have identified that the APOE gene mutation, particularly the rare R136S variant, inhibits cGAS-STING signaling, thereby reducing inflammation in the aging brain and providing protection against Alzheimer's disease.