In his interview, Ono addressed critical issues such as mental health, antisemitism, and the importance of creating a campus environment free from resentment for Jewish students.

Ono emphasized his commitment to combating antisemitism and maintaining open dialogue on campus, drawing from his experiences at the University of Michigan.

He has pledged that DEI programs will not return to UF and has expressed support for Governor Ron DeSantis' initiatives to eliminate DEI offices, a stance he had already taken at Michigan.

He also highlighted the need for universities to resist ideological influences that may stifle debate, asserting that his recent actions are more indicative of his current beliefs than past statements.

UF Board of Trustees Chair Mori Hosseini praised Ono as an accomplished scholar and emphasized his alignment with the university's values, particularly in prioritizing merit and scholarship.

Ono's key goals for his presidency include advancing AI development, enhancing civic education, and increasing medical research initiatives at UF.

During the vetting process, trustees questioned Ono about his past statements on DEI and antisemitism, underscoring the significance of his current stance in light of Florida's educational reforms.

Critics, including prominent figures like Chris Rufo, argue that Ono's appointment could shift UF back toward identity politics, potentially undermining the progress made under his predecessor, Ben Sasse.

The outcome of Ono's confirmation could have significant implications for the direction of higher education in Florida, as other states look to Florida's reforms as a potential model.

On May 27, 2025, the University of Florida's Board of Trustees approved Santa Ono, the former president of the University of Michigan, to lead the university, pending confirmation from the Board of Governors.

Ono's past support for diversity, equity, and inclusion (DEI) initiatives has raised concerns among conservative circles, especially given Florida's current push to eliminate such programs in public universities.

While at the University of Michigan, Ono advocated for DEI programs, including a 'DEI 2.0' initiative, but later dismantled these programs, stating they were divisive and detracted from student success.