AI Uncovers Bacterial Link to Cognitive Decline in Parkinson's, Suggests New Treatment Strategies
June 9, 2025
Promoting a healthy microbiome through oral care, diet, and probiotics may improve disease management and overall health outcomes for Parkinson's patients.
AI was employed to link specific bacterial species and functions to cognitive decline more accurately than traditional methods, paving the way for innovative approaches to understanding Parkinson's disease.
As Parkinson's patients become more reliant on caregivers, basic practices such as oral hygiene and nutrition may be overlooked, emphasizing the need for proactive management to prevent further deterioration.
Dr. Saeed Shoaie emphasized the connection between gut and oral bacteria with neurodegenerative diseases, noting that disruptions in the gut-brain axis may lead to inflammation and neuronal damage.
Dr. Shoaie advocates for maintaining oral and gut health as a strategy to mitigate neurodegenerative processes in Parkinson's patients.
A recent study published in the journal Gut Microbes analyzed 228 samples from various patient groups, including those with mild cognitive impairment and dementia, revealing that toxins produced by harmful bacteria could serve as markers for identifying Parkinson's patients at higher risk of developing dementia.
Dr. Frederick Clasen stated that it remains unclear whether the bacteria cause cognitive decline or if Parkinson's changes enable their growth, but he suggested that these bacteria may contribute to symptom worsening.
The study's results could lead to the development of targeted treatments aimed at altering the gut environment to protect brain health.
Researchers utilized artificial intelligence to connect bacterial shifts to cognitive decline in Parkinson's patients, identifying specific bacterial species that were not detectable through traditional testing methods.
Parkinson's disease is a progressive neurological condition characterized by symptoms such as tremors, depression, balance issues, sleep disturbances, and memory problems, with about one-third of patients eventually developing dementia.
Summary based on 4 sources
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Sources

Eastern Daily Press • Jun 9, 2025
Gut bacteria changes could be ‘warning sign for worsening Parkinson’s symptoms’
Oxford Mail • Jun 9, 2025
Gut bacteria changes could be ‘warning sign for worsening Parkinson’s symptoms’
Reading Chronicle • Jun 9, 2025
Gut bacteria changes could be ‘warning sign for worsening Parkinson’s symptoms’
Chester and District Standard • Jun 9, 2025
Gut bacteria changes could be ‘warning sign for worsening Parkinson’s symptoms’