Anime-Inspired Scientist Revolutionizes Neuroscience With Brain Organoids, Impacting Neurodevelopmental Disorder Research
July 8, 2025
Dr. Qian, an Assistant Professor at the University of Pennsylvania, was inspired to pursue neuroscience by the anime series Evangelion, which led him to study biomedical engineering and develop innovative methods for creating human brain organoids.
His brain organoid technology has revolutionized neuroscience research, allowing the growth of miniature brain structures that have been cited over 2,000 times, significantly impacting the understanding of neurodevelopmental disorders.
Dr. Qian's research has potential therapeutic implications, aiming to develop strategies for early diagnosis and treatment of neurodevelopmental disorders affecting millions of children worldwide.
During the Zika virus outbreak of 2015-2016, Dr. Qian's work provided pivotal evidence linking the virus to microcephaly, which informed CDC guidelines to protect pregnant women.
Dr. Qian's recent study has created a developmental atlas of the human cerebral cortex by analyzing over 18 million brain cells, significantly advancing the understanding of human brain development and neurodevelopmental disorders.
Using MERFISH technology, his research represents one of the most comprehensive analyses of human brain development to date, offering crucial insights into how the cerebral cortex develops.
As he establishes his lab at the University of Pennsylvania, Dr. Qian aims to integrate brain organoid models with spatial omics and human genetics to uncover mechanisms behind disorders like autism and cortical malformations.
Dr. Qian's innovative approach and collaborative spirit position him as a leading figure in neuroscience, with the potential to develop new therapeutic strategies for neurodevelopmental disorders.
He has a strong commitment to science communication, reaching a wide audience on platforms like Bilibili to make neuroscience accessible and inspire future scientists.
He promotes collaboration and open science in his research approach, having been recognized on the Forbes 30 Under 30 list for his contributions to the field.
The interview showcasing Dr. Qian's work is part of Genomic Press's Innovators & Ideas series, which highlights influential scientists and their contributions to advancing scientific knowledge.
As he establishes his lab at the University of Pennsylvania, his research aims to uncover mechanisms behind disorders like autism and malformations of cortical development.
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