A fiery crash on the Hume Highway near Breadalbane involved six semi-trailers carrying flammable cargo, triggering a massive blaze and explosions that destroyed all six trucks and prompted a large exclusion zone and highway closures.

Two trucks entering a roadside rest stop collided, setting off a chain reaction that drew in four more trucks and left six vehicles destroyed.

Initial reports grew from seven to six involved vehicles, with investigators confirming there were no missing drivers and all six trucks were accounted for.

Officials say there were no serious injuries or deaths, crediting swift emergency response and strict safety protocols for the favorable outcome.

Emergency responders deployed seven fire trucks, including two HazMat units, and up to 40 firefighters to control the blaze.

All six truck drivers survived with only minor injuries; two drivers were taken for mandatory testing at Goulburn hospital.

One truck carried eight tonnes of butane cans, contributing to multiple small explosions as crews arrived.

Cargo included butane, resin, memory foam, and alcohol, fueling the fire and requiring precautionary containment around the scene.

Firefighters extinguished the blaze and began cleanup, with a southbound lane reopening at reduced speeds while northbound lanes remained closed.

The Hume Highway remained closed in both directions in the morning, with delays and diversions through Canberra expected as debris and hazmat cleanup continued.

Additional hazardous materials such as alcohol and memory foam were among the cargo, intensifying debris and fire conditions.

A crime scene was established as investigators from the crash investigation unit joined the ongoing inquiry.