However, he faced criticism from Democratic regents for not taking a stronger stance against threats from the Trump administration regarding research funding linked to diversity initiatives.

Ono's departure raises questions about the future direction of the University of Michigan, particularly regarding its athletic programs, which have thrived under his leadership.

Ono's transition to Florida comes at a time when the University of Florida has faced its own challenges under President Sasse, including student protests and political controversies.

While his departure was somewhat unexpected, insiders suggest it may not have been entirely surprising given the tumultuous nature of his presidency.

Ono's time at Michigan followed a period of significant turmoil, including a major sexual assault scandal that resulted in a $490 million settlement.

As he prepares to take on his new role, Ono will need to navigate the complexities of Florida's higher education landscape and build consensus following Sasse's controversial tenure.

Santa Ono has announced his intention to leave his role as president of the University of Michigan to become the next president of the University of Florida, pending approval from the Florida Board of Governors.

During his presidency at Michigan, Ono dealt with significant challenges, including campus unrest related to the Gaza-Hamas war and controversies surrounding the dismantling of the Office of Diversity, Equity, and Inclusion.

His tenure was also marked by ongoing litigation related to the Dr. Robert Anderson sexual abuse scandal and reforms to the university's sexual misconduct policies.

Despite these challenges, Ono's leadership saw advancements in areas such as artificial intelligence, sustainability, and the expansion of the Go Blue Guarantee for low-income students.

He joined the University of Michigan in late 2022, succeeding Mark Schlissel, and during his tenure, the men's basketball team achieved notable success.

On May 6, 2025, Ono is scheduled to visit the University of Florida campus to engage with students, faculty, and administrators as part of his transition.