In her final Instagram post from February 2025, Lewis emphasized the importance of cancer prevention, urging her followers to learn about avoiding the disease.

Despite her declining health, she continued to share her experiences with terminal breast cancer, advocating for awareness and early detection.

In an essay for Essence published in January 2025, she encouraged women to be vigilant about their health and listen to their bodies regarding cancer detection.

Diagnosed with stage three breast cancer in 2020, Lewis openly discussed her journey and the importance of early detection, regretting her previous fear of mammograms.

She opted against conventional treatments like chemotherapy, believing in the impact of lifestyle changes and environmental factors on health.

Ananda Lewis, a former MTV VJ and BET personality, passed away on June 11, 2025, at the age of 52 after a long battle with breast cancer.

Her sister Lakshmi announced her death on social media, expressing a heartfelt tribute and stating, 'She fought with grace and truth. Now she is free.'

Lewis was a prominent figure on MTV in the late 1990s, known for hosting 'Total Request Live' and 'Hot Zone', and her own talk show, 'The Ananda Lewis Show', in 2001.

Her legacy is one of authenticity and advocacy, inspiring many through her personal journey and commitment to social causes.

MTV expressed condolences on social media, highlighting Lewis's influence on a generation of music fans and her ability to connect them with their favorite celebrities.

In addition to her television work, she was active in social causes, serving as a spokesperson for Reading is Fundamental and participating in mental health campaigns.

Ananda became a mother in 2011 to her son, Langston, who brought her joy and purpose despite her health challenges.