The Pan Mass Challenge, now in its 47th year, kicked off in Massachusetts as thousands of cyclists embarked on a two-day, 177-mile fundraiser to support cancer research.

For the first time, the PMC started at the College of the Holy Cross in Worcester, shifting from its traditional Sturbridge launch and using Worcester as the hub for day one.

Riders gathered at the Mass Maritime Academy for day one, with Worcester’s new start line at Holy Cross drawing big crowds and volunteers for a sprawling, 14-route weekend.

This is an ongoing story with updates promised as more information becomes available.

Among local participants from Watertown are 19 named residents who are associated with PMC profiles, highlighting community involvement.

Media content includes video of riders arriving in Worcester and coverage from CBS/Boston, underscoring the event’s profile.

Readers can find more information on the official PMC website.

Organizers anticipate about 6,500 riders and 4,000 volunteers this weekend, with participants traveling from 47 states and 12 countries.

Riders and sponsors shared personal motivations, including riding in memory of loved ones and honoring children affected by cancer, with teams like Team Kermit raising substantial funds for pediatric cancer research.

Local business and PMC volunteers weighed in on the new start location, noting community impact and operational logistics.

Riders picked up materials at the Luth Athletic Complex as Holy Cross repurposed its basketball court for merchandise distribution.

Bruce Springsteen delivered a motivational message during Worcester’s opening ceremonies, adding star power to the event.