WHO Updates COVID-19 Guidelines: New Stance on Antibiotic Use Amid Evolving Virus
August 6, 2025
To maintain focus and relevance, the WHO has also removed general medical recommendations that are no longer specific to COVID-19 management.
These revisions come in light of a notable reduction in infection rates and disease severity, alongside the integration of COVID-19 care into regular healthcare systems.
Despite these advances, including widespread vaccine rollouts, COVID-19 continues to infect thousands daily, underscoring the need for updated treatment strategies.
The WHO emphasizes that while vaccination and immunity have led to reduced hospitalization and mortality rates, the SARS-CoV-2 virus continues to evolve, impacting its infectivity and disease severity.
This ongoing evolution of the virus necessitates continuous updates to clinical guidelines to ensure effective patient care.
In its latest recommendations, the WHO advises against the use of antibiotics in COVID-19 patients unless there is a suspicion of a concurrent bacterial infection.
This recommendation is particularly strong for patients with mild COVID-19 and is conditionally advised for those with severe cases.
Overall, these updated guidelines aim to provide clearer guidance for clinicians, health workers, and hospital administrators involved in the care of COVID-19 patients.
The World Health Organization (WHO) has released updated guidelines that reflect significant changes in COVID-19 epidemiology, severity, and the healthcare context since the pandemic began in 2020.
For non-severe COVID-19 patients with low suspicion of bacterial infection, the WHO recommends against empirical antibiotics, extending this suggestion to severe cases as well.
Summary based on 5 sources
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Sources

The Hindu • Aug 6, 2025
WHO updates COVID-19 guidelines: antibiotics advised only with suspected bacterial infection
Business Standard • Aug 6, 2025
WHO updates recommendations on use of antibiotics for Covid-19 patients
Devdiscourse • Aug 6, 2025
WHO Updates Antibiotic Guidelines for COVID-19 Management | Health
https://www.oneindia.com • Aug 6, 2025
WHO Updates Recommendations on Antibiotic Use for COVID-19 Patients Without Bacterial Infections